| Autor: |
Nicole Habel, Jeanne du Fay de Lavallaz, Margaret Infeld, Jodi L. Koehler, Paul D. Ziegler, Daniel L. Lustgarten, Markus Meyer |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 17, Iss , Pp 200182- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2772-4875 |
| DOI: |
10.1016/j.ijcrp.2023.200182 |
| Popis: |
Background: Lower heart rates (HRs) prolong diastole, which increases filling pressures and wall stress. As a result, lower HRs may be associated with higher brain natriuretic peptide (BNP) levels and incident atrial fibrillation (AF). Beta-blockers may increase the risk for AF due to suppression of resting HRs. Objective: Examine the relationships of HR, BNP, beta-blockers and new-onset AF in the REVEAL-AF and SPRINT cohort of subjects at risk for developing AF. Methods: In REVEAL-AF, 383 subjects without a history of AF and a mean CHA2DS2VASC score of 4.4 ± 1.3 received an insertable cardiac monitor and were followed up to 30 months. In SPRINT, 7595 patients without prior history of AF and a mean CHA2DS2VASC score of 2.3 ± 1.2 were followed up to 60 months. Results: The median daytime HR in the REVEAL-AF cohort was 75bpm [IQR 68–83]. Subjects with below-median HRs had 2.4-fold higher BNP levels compared to subjects with above-median HRs (median BNP [IQR]: 62 pg/dl [37−112] vs. 26 pg/dl [13–53], p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
