| Autor: |
Nuha M.M. Alanazi, Ibrahim O. Althobaiti, Yasser A. El-Ossaily, Wael A.A. Arafa, Mohamed Y. El-Sayed, Hamud A. Altaleb, Hanaa Y. Ahmed, Mahmoud S. Tolba |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 16, Iss 3, Pp 104543- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2023.104543 |
| Popis: |
This study demonstrates the design and synthesis of heterocyclic compounds with diverse biological effects. Using an ionic liquid catalyst, a sonosynthetic approach for the assembly of bis-arylidene cycloalkanone derivatives (bis-chalcones) has been reported. Three cancer cell lines Hepatocellular carcinoma cells (HepG-2), Breast carcinoma cells (MCF-7), and Lung carcinoma cells (A-549) were utilized to investigate the antiproliferative effects of some selected samples. Many evaluated drugs exhibited good to moderate cytotoxicity against the examined cell lines. Notably, the IC50 values for the S-alkyl derivatives ranged from 2.86 to 13.14 µg/mL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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