| Autor: |
Yue Tang, Ming-Hao Dong, Xiao-Wei Pang, Hang Zhang, Yun-Hui Chu, Luo-Qi Zhou, Sheng Yang, Lu-Yang Zhang, Yun-Fan You, Li-Fang Zhu, Wei Wang, Chuan Qin, Dai-Shi Tian |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1742-2094 |
| DOI: |
10.1186/s12974-024-03281-7 |
| Popis: |
Abstract Circulating miR-30c-2-3p has been closely related to vascular diseases, however, its role and underlying mechanisms in ischemic stroke remained unclear. Our study addressed this gap by observing elevated levels of exosomal miR-30c-2-3p in patients with acute ischemic stroke due to large artery atherosclerosis. Further investigation revealed that these exosomal miR-30c-2-3p primarily originated from macrophages within atherosclerotic plaques, exacerbating ischemic stroke by targeting microglia. Exosomes enriched with miR-30c-2-3p increased microglial inflammatory properties in vivo and aggravated neuroinflammation by inhibiting SMAD2. In summary, our findings revealed a novel mechanism whereby macrophage-derived foam cells within atherosclerotic plaques secrete exosomes with high levels of miR-30c-2-3p, thus aggravate brain damage during ischemic stroke, which serves as crucial link between the periphery and brain. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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