| Autor: |
Myat Nyan, Daisuke Sato, Mitsumasa Oda, Tetsu Machida, Hiroshi Kobayashi, Takahiro Nakamura, Shohei Kasugai |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 384-386 (2007) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.SC0070184 |
| Popis: |
Simvastatin, a cholesterol synthesis inhibitor, enhances BMP2 expression in osteoblasts. The purpose of the present study was to examine whether simvastatin stimulates bone regeneration when combined with calcium sulfate as a carrier. Critical-sized bone defects in rat calvaria were treated with calcium sulfate or with combination of 1 mg simvastatin and calcium sulfate. In the combination group, although the least amount of bone formation with intense soft tissue inflammation was observed at 2 and 4 weeks, remarkable bone formation was evident at 8 weeks. Conclusively, the combination of simvastatin and calcium sulfate stimulated bone regeneration in spite of the inflammatory response. Keywords:: simvastatin, calcium sulfate, bone formation |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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