Pathogenic role of Twist-1 protein in hydatidiform molar pregnancies and investigation of its potential diagnostic utility in complete moles

Autor:	Behnaz Jahanbin, Soheila Sarmadi, Dorsa Ghasemi, Fatemeh Nili, Jafar-Ali Moradi, Soha Ghasemi
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Hydatidiform mole Complete mole Partial mole Diagnosis Immunohistochemistry Twist-1 Pathology RB1-214
Zdroj:	Diagnostic Pathology, Vol 18, Iss 1, Pp 1-8 (2023)
Druh dokumentu:	article
ISSN:	1746-1596
DOI:	10.1186/s13000-023-01329-5
Popis:	Abstract Background Complete and partial moles (PM) are the most common gestational trophoblastic diseases. Due to some overlapping morphological findings, ancillary studies may be necessary. Methods In this cross-sectional study, 47 cases of complete mole (CM) and 40 cases of PM were randomly selected based on histopathological criteria. Only those cases that were agreed upon by two expert gynecological pathologists and confirmed by the P57 IHC study were included. The expression level of the Twist-1 marker in villi stromal cells, as well as syncytiotrophoblasts, was evaluated quantitatively (percentage of positive cells), qualitatively (staining intensity) and as a total comprehensive score. Results Expression of Twist-1 is higher and more intense in villous stromal cells of CMs (p
Databáze:	Directory of Open Access Journals
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