Reciprocal impacts of telomerase activity and ADRN/MES differentiation state in neuroblastoma tumor biology

Autor: Eun Young Yu, Syed S. Zahid, Sarah Aloe, Erik Falck-Pedersen, Xi Kathy Zhou, Nai-Kong V. Cheung, Neal F. Lue
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02821-8
Popis: Yu et al. identify marked differences in the telomere and immunologic profiles of neuroblastoma cell lines displaying MES and ADRN lineage characteristics. They show that pharmacologically converting ADRN into MES cells triggers associated switch in telomere/immunologic protein profiles whereas inhibiting telomerase activity in ADRN cells induces reversible conversion into MES cells.
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