New concepts regarding micro/nanopharmaceutical polymer systems with applications in ophthalmology and neurosciences
| Autor: | Fotios A. Gardikiotis, Catalina A. Peptu, Marcel Popa, Danut Costin |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Romanian Neurosurgery, Vol 18, Iss 3 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1220-8841 2344-4959 |
| Popis: | Particulate systems like micro/nanoparticles have been used as a physical approach to modify the pharmacokinetic and pharmacodynamic properties of various types of drug molecules increasing this way the drug bioavailability and avoiding the toxic level. The major advantages of the particulate systems include the protection of the drug entity in the systemic circulation, restriction access of the drug to the chosen sites and delivery of the drug at a controlled and sustained rate to the site of action. Various materials have been used in the formulation of micro/nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Each class of materials (metals, lipids, polymers) presents advantages which make them suitable for different classes of applications. This paper focuses mainly on polymer particulate systems due to their large applicability area given by the diversity of the polymers properties. We review various aspects of micro/nanoparticle formulation including preparation, release mechanisms, effect of their characteristics and their applications in the field of ophthalmology and neurosciences. Some of the most interesting applications of polymer micro/nanoparticulates in glaucoma, retinal disorders and optical nerve disorders, respectivelly in neurology and neurosurgery are presented. |
| Databáze: | Directory of Open Access Journals |
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