| Autor: |
Jip Aarts, Shalina R. D. Saddal, Judith E. Bosmans, Vincent de Groot, Brigit A. de Jong, Martin Klein, Marit F. L. Ruitenberg, Frederieke G. Schaafsma, Esther C. F. Schippers, Menno M. Schoonheim, Bernard M. J. Uitdehaag, Sabina van der Veen, Pauline T. Waskowiak, Guy A. M. Widdershoven, Karin van der Hiele, Hanneke E. Hulst, on behalf of the Don’t be late! consortium |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Neurology, Vol 24, Iss 1, Pp 1-15 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2377 |
| DOI: |
10.1186/s12883-023-03513-y |
| Popis: |
Abstract Background Up to 65% of people with multiple sclerosis (PwMS) develop cognitive deficits, which hampers their ability to work, participating in day-to-day life and ultimately reducing quality of life (QoL). Early cognitive symptoms are often less tangible to PwMS and their direct environment and are noticed only when symptoms and work functioning problems become more advanced, i.e., when (brain) damage is already advanced. Treatment of symptoms at a late stage can lead to cognitive impairment and unemployment, highlighting the need for preventative interventions in PwMS. Aims This study aims to evaluate the (cost-) effectiveness of two innovative preventative interventions, aimed at postponing cognitive decline and work functioning problems, compared to enhanced usual care in improving health-related QoL (HRQoL). Methods Randomised controlled trial including 270 PwMS with mild cognitive impairment, who have paid employment ≥ 12 h per week and are able to participate in physical exercise (Expanded Disability Status Scale |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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