Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients

Autor:	Somayeh Pouriamehr, Haleh Barmaki, Mozhdeh Rastegary, Farzaneh Lotfi, Mohsen Nabi Afjadi
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Metabolic syndrome X Insulin-like growth factor Insulin-like growth factor receptor Medicine Biology (General) QH301-705.5 Science (General) Q1-390
Zdroj:	BMC Research Notes, Vol 12, Iss 1, Pp 1-5 (2019)
Druh dokumentu:	article
ISSN:	1756-0500
DOI:	10.1186/s13104-019-4492-9
Popis:	Abstract Objective The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism. Unregulated levels of IGFs/IGFBPs have been associated with the development of glucose intolerance and metabolic syndrome X (MSx). We hypothesized that change of IGFs/IGFBPs levels could increase the risk of MSx; thus, this study aimed to evaluate the serostatus of IGFs/IGFBPs in individuals with MSx. Results After adjustment for metabolic parameters, MSx patients had a lower level of IGF-1, IGFBP-1, and IGFBP-2 compared with subjects in the control group. Further analysis revealed a positive correlation between serum levels of IGF-1 and IGF-2 (p
Databáze:	Directory of Open Access Journals
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