Effects of the mediterranean diet versus low-fat diet on metabolic syndrome outcomes: A systematic review and meta-analysis of randomized controlled trials

Autor: Alyssa Milano, Suad Kabbaha, Kristian Thorlund
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Human Nutrition & Metabolism, Vol 30, Iss , Pp 200175- (2022)
Druh dokumentu: article
ISSN: 2666-1497
DOI: 10.1016/j.hnm.2022.200175
Popis: Several clinical studies have attributed the Mediterranean diet (MedDiet) to desirable metabolic health outcomes, but literature is saturated with studies conducted in Mediterranean regions questioning the diets applicability in non-Mediterranean countries. This review aimed to determine the effectiveness of MedDiet compared to a low-fat diet (LF-Diet) on metabolic components in those with or at risk of developing Metabolic Syndrome (MetS) in non-Mediterranean countries. We searched Medline, Embase and Global Health for randomized controlled trials published until October 2022 and a clinical trial register for ongoing studies. We identified 13 published trials (n = 1921) and 2 ongoing trials that met inclusion criteria. Random effects meta-analysis, yielded a statistically significant reduction in total cholesterol (MD -7.97, 95%CI -14.82 to −1.11) and systolic blood pressure (MD -2.04 mg/dl, 95%CI -3.68 to −0.39). Small non-significant pooled mean difference (MD) was observed for seven other MetS risk factors (body weight, waist circumference, diastolic blood pressure, blood glucose, triglycerides, LDL and HDL-cholesterol). Further inquiry is required to enhance certainty in estimates before health care providers can make an informed decision about possible dietary changes in MetS management and comorbidity prevention.
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