How the Nature of an Alpha-Nucleophile Determines a Brønsted Type-Plot and Its Reaction Pathways. An Experimental Study

Autor:	Paola R. Campodónico, Ricardo A. Tapia, Cristian Suárez-Rozas
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	SNAr reactions mechanisms hydrogen bond interaction reactivity brønsted type-plots Chemistry QD1-999
Zdroj:	Frontiers in Chemistry, Vol 9 (2022)
Druh dokumentu:	article
ISSN:	2296-2646 54556902
DOI:	10.3389/fchem.2021.740161
Popis:	The reactions between 2-chloro-5-nitro pyrimidine with a serie of α-nucleophile derivatives were kinetically evaluated. The kinetic study was carried out in aqueous media and the data shown an unusual split on the Brønsted type-plot, opening a controversial discussion based on reactivities and possible reaction pathways. These split Brønsted type-plots are discussed over the hypothetical transition state (TS) structures associated to concerted or stepwise mechanisms with emphasis on hydrogen bond interactions between electrophile/nucleophile pair able to determine the reactivities and the plausible reaction routes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1ed7596fb9b545569025451ecdf3231e Zobrazit plný text záznamu View record in DOAJ