| Autor: |
Cepeda Libia A, Garcés Maria F, González C Ruth, Bravo Susana B, Caminos Jorge E, González Adriana C, Cordido Fernando, López Miguel, Diéguez Carlos |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Reproductive Biology and Endocrinology, Vol 6, Iss 1, p 14 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1477-7827 |
| DOI: |
10.1186/1477-7827-6-14 |
| Popis: |
Abstract Background Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta. Methods In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction. Results Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction. Conclusion These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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