TBX2 specifies and maintains inner hair and supporting cell fate in the Organ of Corti

Autor: Marina Kaiser, Timo H. Lüdtke, Lena Deuper, Carsten Rudat, Vincent M. Christoffels, Andreas Kispert, Mark-Oliver Trowe
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35214-4
Popis: Inner hair cells are essential for hearing but the molecular drivers of their differentiation have remained enigmatic. Here, the authors show that the transcription factor TBX2 has a key function in inducing and maintaining inner hair cell fate.
Databáze: Directory of Open Access Journals