Intramuscular Short-term ACTH Test for the Determination of Adrenal Function in Children: Safe, Effective and Reliable

Autor:	Elif Özsu, Zeynep Şıklar, Esra Bilici, Ayşegül Ceran, Rukiye Uyanık, Tuğba Çetin, Zehra Aycan, Merih Berberoğlu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	adrenal insufficiency intramuscular acth childhood reliability Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	JCRPE, Vol 12, Iss 3, Pp 241-247 (2020)
Druh dokumentu:	article
ISSN:	1308-5727 1308-5735
DOI:	10.4274/jcrpe.galenos.2019.2019.0099
Popis:	Objective:Standard short adrenocorticotropic hormone (ACTH) stimulation test (SST) has traditionally been used for assessing adrenal gland fuction by intravenous (iv) application. However the iv form is not readily available in all countries, including Turkey. The aim of this study was to evaluate the effectiveness of the intramuscular (im) SST.Methods:Patients underwent im SST with suspected adrenal insufficiency (AI) and hyperandrogenism. The SSTs were done with 250 mcg ACTH (Synacthen Depot ampul, concentration 1 mg/mL). The cases were divided into two groups: suspected AI (group 1 n=87); and hyperandrogenism group (group 2 n=124). Definite AI was defined as peak cortisol
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cd1ec571dee24d0d86740a83d408a8cb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF