The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction

Autor: Ahmad Luqman-Fatah, Yuzo Watanabe, Kazuko Uno, Fuyuki Ishikawa, John V. Moran, Tomoichiro Miyoshi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-26 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-35757-6
Popis: Proteomic analyses revealed that a group of interferon-stimulated genes suppresses LINE-1 retrotransposon activities, including HELZ2, which reduces LINE-1 RNA and the associated innate immune response levels.
Databáze: Directory of Open Access Journals