High-dose chemotherapy and stem-cell rescue for salvage therapy for relapsed malignant mixed ovarian germ cell tumor: A case report

Autor: Sarah Sears, Sareena Singh, Hadi Shojaei, Raymond Redline, Kimberly Resnick
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Gynecologic Oncology Reports, Vol 22, Iss C, Pp 72-74 (2017)
Druh dokumentu: article
ISSN: 2352-5789
DOI: 10.1016/j.gore.2017.09.013
Popis: Background: Malignant ovarian germ cell tumors are rare, and often treatable with surgery and chemotherapy. Few data are available for treatment of platinum-resistant tumors. Case: A 31 year old gravida 0 with a 20 cm pelvic mass was found to have a malignant ovarian germ cell tumor after she underwent debulking surgery. She initially responded to chemotherapy; however her AFP began to rise before all cycles were completed. She underwent additional debulking surgery that was again suboptimal. She was then referred for salvage therapy with high-dose chemotherapy with stem cell transplant, which was successful and she has had no evidence of disease for over two years. Conclusion: High-dose chemotherapy with stem cell transplant is a viable salvage therapy for patients with platinum-resistant germ cell tumors.
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