Elevated SIRT2 of serum exosomes is positively correlated with diagnosis of acute ischemic stroke patients

Autor: Wenmei Lu, Duanlu Hou, Xin Chen, Ping Zhong, Xueyuan Liu, Danhong Wu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Neurology, Vol 23, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 1471-2377
DOI: 10.1186/s12883-023-03348-7
Popis: Abstract Background Silent Information Regulator 2 (SIRT2) protein inhibition has been shown to play a neuroprotective role in acute ischemic stroke (AIS) in mice. However, its role in AIS patients has not been fully understood. In this study, we aimed to analyze SIRT2 protein expression in serum exosomes of AIS and non-AIS patients, and evaluate its potential role in diagnosis and prognosis of AIS. Methods Serum exosomes from 75 non-AIS subjects and 75 AIS patients were isolated. The SIRT2 protein levels in exosomes were analyzed using enzyme linked immunosorbent assay (ELISA). The National Institutes of Health Stroke Scale (NIHSS) was used to evaluate the severity of the disease. The modified Rankin Scale (mRS) was employed to assess the functional outcomes of the patients at 3-months following stroke onset. Results The SIRT2 protein concentration of serum exosomes were higher in AIS patients than non-AIS patients (p
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