| Autor: |
Mei Bai, De-Yu Miao, Ya-Kun Li, Jian-Dong Lyu, Zhi-Qiang Liu, Ya-Li Li, Xiang-Dong Guo |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Guoji Yanke Zazhi, Vol 23, Iss 12, Pp 2035-2039 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1672-5123 |
| DOI: |
10.3980/j.issn.1672-5123.2023.12.19 |
| Popis: |
AIM: To investigate the effects of ginsenoside Rg1 injection combined with inosine tablets and vitamin B1 on serum brain-derived neurotrophic factor(BDNF), pituitary adenylate cyclase activating polypeptide(PACAP)and clinical efficacy in primary retinitis pigmentosa.METHODS: A total of 50 patients(100 eyes)with primary retinitis pigmentosa who admitted to the Department of Ophthalmology, the Second Affiliated Hospital of Hebei North University from August 2019 to March 2022 were selected as the research object. They were divided into the study group and the control group according to random number table, with 50 eyes in each group. Patients in the control group were treated with inosine tablets and vitamin B1, while patients in the study group were treated with ginsenoside Rg1 injection on the basis of the control group. The expression of BDNF and PACAP in serum, electroretinogram and spectral-domain optical coherence tomography(SD-OCT)were compared before and after treatment, and the retinal thickness(RT), mean deviation(MD), clinical efficacy and safety indexes were compared between the two groups.RESULTS: There were no differences in the MD of the two groups before treatment(t=1.670, P=0.098), while the MD of the study group was significantly lower than that of the control group after treatment(t=3.628, P0.05). After treatment, the results of dark adaptation in the study group were significantly better than those in the control group(all P0.05). After treatment, the results of electroretinogram adaptation in the study group were significantly better than those in the control group(all P0.05). BDNF and PACAP in the study group were higher than those of the control group after treatment(all P |
| Databáze: |
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| Externí odkaz: |
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