Multiomics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation

Autor: Chongyang Chen, Jing Wang, Chao Yang, Haitao Yu, Bingge Zhang, Xiao Yang, Bocheng Xiong, Yongmei Xie, Shupeng Li, Zaijun Zhang, Feiqi Zhu, Jianjun Liu, Gong‐Ping Liu, Xifei Yang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: MedComm, Vol 4, Iss 3, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2688-2663
40618773
DOI: 10.1002/mco2.252
Popis: Abstract Sleep insufficiency is associated with various disorders; the molecular basis is unknown until now. Here, 14 males and 18 females were subjected to short‐term (24 h) sleep deprivation, and donated fasting blood samples prior to (day 1) and following (days 2 and 3) short‐term sleep deprivation. We used multiple omics techniques to examine changes in volunteers’ blood samples that were subjected to integrated, biochemical, transcriptomic, proteomic, and metabolomic analyses. Sleep deprivation caused marked molecular changes (46.4% transcript genes, 59.3% proteins, and 55.6% metabolites) that incompletely reversed by day 3. The immune system in particular neutrophil‐mediated processes associated with plasma superoxidase dismutase‐1 and S100A8 gene expression was markedly affected. Sleep deprivation decreased melatonin levels and increased immune cells, inflammatory factors and c‐reactive protein. By disease enrichment analysis, sleep deprivation induced signaling pathways for schizophrenia and neurodegenerative diseases enriched. In sum, this is the first multiomics approach to show that sleep deprivation causes prominent immune changes in humans, and clearly identified potential immune biomarkers associated with sleep deprivation. This study indicated that the blood profile following sleep disruption, such as may occur among shift workers, may induce immune and central nervous system dysfunction.
Databáze: Directory of Open Access Journals
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