Impact of N6-methyladenosine (m6A) modification on immunity

Autor:	Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha, Mohamed Z. Gad
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	N6-methyl-adenosine Innate Adaptive Immunity m6A writers m6A erasers Medicine Cytology QH573-671
Zdroj:	Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-12 (2022)
Druh dokumentu:	article
ISSN:	1478-811X
DOI:	10.1186/s12964-022-00939-8
Popis:	Abstract N6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels. The dysregulation of m6A modification has been implicated in various human diseases. Thus, m6A modification has now become a research hotspot for its potential therapeutic applications in the treatment of various cancers and diseases. The immune system is essential to provide defense against infections and cancers. This review summarizes the current knowledge about the roles of m6A in regulating immune cell functions and immune responses. Video abstract
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1e867e9c4a0f4a868c688ddb2c2827df Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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