The effect of bismuth subcitrate in patients with diarrhea predominant irritable bowel syndrome
| Autor: | Kalani M, Foroutan H, Rahimi R, Ghofrani H, Ahadpoor Behnami Sh |
|---|---|
| Jazyk: | perština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Tehran University Medical Journal, Vol 68, Iss 6, Pp 335-340 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1683-1764 1735-7322 |
| Popis: | "nBackground: The irritable bowel syndrome (IBS) is one of the most common chronic medical conditions. Various mechanisms, including altered gut flora and/or small bowel bacterial overgrowth, have been suggested to play a role in the development of gas-related symptoms aim of study. The clinical evidence of small intestinal bacterial overgrowth as an important etiology of irritable bowel syndrome continues to accumulate. Clinical symptoms of bacterial overgrowth and irritable bowel syndrome are similar; however, a definitive cause-and-effect relationship remains unproven. It is unclear whether motility dysfunction causes bacterial overgrowth or gas products of"nenteric bacteria affect intestinal motility in irritable bowel syndrome."n "nMethods: In a randomized double-blind placebo-controlled trial consisting of treatment with bismuth subcitrate. Primary efficacy variable was subjective symptoms; frequency of abdominal pain, Number of bowel movement & Bloating/distension."n "nResults: 119 patients were enrolled (59 bismuth subcitrate and 60 placebo recipients). At the end of phase 2, all symptom scores dropped significantly both in bismuth subcitrate and placebo group (p |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|