| Autor: |
Thomas P C Dorlo, Pieter P A M van Thiel, Gerard J Schoone, Ymkje Stienstra, Michèle van Vugt, Jos H Beijnen, Peter J de Vries |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
PLoS Neglected Tropical Diseases, Vol 5, Iss 12, p e1436 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1935-2735 |
| DOI: |
10.1371/journal.pntd.0001436 |
| Popis: |
Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ∼1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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