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Abstract Study design In vitro biomechanical study investigating the coupled motions of the whole normative human thoracic spine (TS) and lumbar spine (LS) with rib cage. Objective To quantify the region‐specific coupled motion patterns and magnitudes of the TS, thoracolumbar junction (TLJ), and LS simultaneously. Background Studying spinal coupled motions is important in understanding the development of complex spinal deformities and providing data for validating computational models. However, coupled motion patterns reported in vitro are controversial, and no quantitative data on region‐specific coupled motions of the whole human TS and LS are available. Methods Pure, unconstrained bending moments of 8 Nm were applied to seven fresh‐frozen human cadaveric TS and LS specimens (mean age: 70.3 ± 11.3 years) with rib cages to elicit flexion‐extension (FE), lateral bending (LB), and axial rotation (AR). During each primary motion, region‐specific rotational range of motion (ROM) data were captured. Results No statistically significant, consistent coupled motion patterns were observed during primary FE. During primary LB, there was significant (p |