Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs

Autor: Frederik Loewenstein, Sabrina Becker, Josef Kuehling, Hansjörg Schrade, Mirjam Lechner, Robert Ringseis, Klaus Eder, Andreas Moritz, Gerald Reiner
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Veterinary Research, Vol 18, Iss 1, Pp 1-12 (2022)
Druh dokumentu: article
ISSN: 1746-6148
DOI: 10.1186/s12917-021-03107-1
Popis: Abstract Background Swine inflammation and necrosis syndrome (SINS) can lead to significant clinical alterations at tail, ears, claws and other parts of the body in suckling piglets, weaners and fatteners. Clinical findings are associated with vasculitis, intima proliferation and thrombosis. The syndrome can be found in newborns, indicating a primarily endogenous aetiology. It has been hypothesized that SINS is triggered by gut-derived microbial-associated molecular patterns, causing derangements in liver metabolism and activity of peripheral white blood cells involving inflammation and blood haemostasis. In order to characterize these metabolic derangements of SINS for the first time, red and white blood counts, parameters of blood haemostasis, serum metabolites and acute phase proteins in the serum were analysed in 360 piglets, weaners and fatteners, each with significantly different SINS scores. Results SINS scores and haematological/clinical chemical parameters were significantly associated (P
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