Evaluation of the effects of atorvastatin on renal ischemia-reperfusion in diabetic rats
| Autor: | Leila Pirmoradi, Saeed Purdian, Ramesh Rahagh, Foruzan Hosseini |
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| Jazyk: | perština |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | مجله علمی دانشگاه علوم پزشکی کردستان, Vol 25, Iss 5, Pp 11-21 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1560-652X 2345-4040 |
| Popis: | Background and Aim: Statins are among extensively used medications in diabetic patients. This study was designed to assess the outcome of atorvastatin pretreatment in renal ischemia- reperfusion in diabetic rats. Material and Methods: Wistar male rats (180-230 gr) were divided into 5 groups: normal control (CN), atorvastatin control (5 mg/kg) (CA), diabetic control (CD), diabetic group receiving atorvastatin 0.5 mg/kg (DA/a), diabetic group receiving atorvastatin 5 mg/kg (DA/b). Affter induction of type II diabetes by injection of nicotinamide and streptozotocin, the rats received daily atorvastatin or normal saline gavage for 2 months. Then, under anesthesia ischemia was induced for 45 min followed by reperfusion for 24 h. Blood and urine samples were collected for the measurement of lipid profile and renal function indices. Statistical analysis was performed by one-way analysis of variance and Tukey post-hoc test. Results: Total cholesterol and LDL were reduced in the group receiving atorvastatin (5 mg/kg) (P |
| Databáze: | Directory of Open Access Journals |
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