Evaluation of transfusion-related complications along with estimation of inhibitors in patients with hemophilia: A pilot study from a single center
| Autor: | Anju Dubey, Anupam Verma, Priti Elhence, Prashant Agarwal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Asian Journal of Transfusion Science, Vol 7, Iss 1, Pp 8-10 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0973-6247 1998-3565 |
| DOI: | 10.4103/0973-6247.106714 |
| Popis: | Background: Apart from inhibitor development in patients with hemophilia (PWH) the old problems of blood borne viral infections and red cell alloimmunization still persist in PWH from developing countries. This study was planned to detect the presence of inhibitors in our PWH and to determine the presence of transfusion transmitted infections (TTI) markers and clinically significant red cell alloantibodies in these patients. Materials and Methods: One hundred fourteen PWH were screened for various laboratory tests. Screening for inhibitors was done by mixing study. Blood grouping, TTI testing and red cell alloantibody detection were done as per the departmental standard operating procedures. Results: Out of 114 patients evaluated 98(86%) had hemophilia A and remaining 16(14%) had hemophilia B. Five (5.1%) patients of hemophilia A were positive on inhibitor screening. On Bethesda assay, one patient was high responder (14.4 BU/ml) and rest 4 were low responders ( |
| Databáze: | Directory of Open Access Journals |
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