Contribution of genetic factors to high rates of neonatal hyperbilirubinaemia on the Thailand-Myanmar border.

Autor: Germana Bancone, Gornpan Gornsawun, Pimnara Peerawaranun, Penporn Penpitchaporn, Moo Kho Paw, Day Day Poe, December Win, Naw Cicelia, Mavuto Mukaka, Laypaw Archasuksan, Laurence Thielemans, Francois Nosten, Nicholas J White, Rose McGready, Verena I Carrara
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLOS Global Public Health, Vol 2, Iss 6, p e0000475 (2022)
Druh dokumentu: article
ISSN: 2767-3375
DOI: 10.1371/journal.pgph.0000475
Popis: Very high unconjugated bilirubin plasma concentrations in neonates (neonatal hyperbilirubinaemia; NH) may cause neurologic damage (kernicterus). Both increased red blood cell turn-over and immaturity of hepatic glucuronidation contribute to neonatal hyperbilirubinaemia. The incidence of NH requiring phototherapy during the first week of life on the Thailand-Myanmar border is high (approximately 25%). On the Thailand-Myanmar border we investigated the contribution of genetic risk factors to high bilirubin levels in the first month of life in 1596 neonates enrolled in a prospective observational birth cohort study. Lower gestational age (
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