Association of proteinuria threshold in pre-eclampsia with maternal and perinatal outcomes: a nested case control cohort of high risk women.

Autor: Kate Bramham, Carlos E Poli-de-Figueiredo, Paul T Seed, Annette L Briley, Lucilla Poston, Andrew H Shennan, Lucy C Chappell
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 10, p e76083 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0076083
Popis: OBJECTIVES:To evaluate occurrence of adverse maternal and perinatal outcomes with different thresholds of proteinuria (300-499 mg and ≥500 mg/24 hours) in pre-eclamptic women, comparing outcomes against women with chronic and gestational hypertension. DESIGN:Secondary analysis of the Vitamins in Pre-Eclampsia Trial. SETTING:25 UK hospitals in ten geographical areas. POPULATION:946 women with pre-existing risk factors for pre-eclampsia. METHODS:Women with pre-eclampsia and proteinuria 300-499 mg/24 h (PE300, referent group, n=60) or proteinuria ≥500 mg/24 h (PE500, n=161) were compared with two groups of non-proteinuric women with chronic hypertension (CHT, n=615) or gestational hypertension (GH, n=110). MAIN OUTCOME MEASURES:MATERNAL: progression to severe hypertension. Perinatal: small for gestational age (SGA)
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