Clinicopathologic characteristics, pathology, and prognosis of 77 dogs with focal segmental glomerulosclerosis

Autor: Sarah K. Lorbach, Jessica A. Hokamp, Jessica M. Quimby, Rachel E. Cianciolo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 34, Iss 5, Pp 1948-1956 (2020)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.15837
Popis: Abstract Background Focal segmental glomerulosclerosis (FSGS) is a common cause of nonimmune complex glomerulopathy and the prognosis and clinicopathologic findings associated with this condition have not been described in dogs. Objective To characterize the presentation and identify clinical factors associated with the survival of dogs with FSGS. Animals Seventy‐seven dogs diagnosed with FSGS based on evaluation of renal biopsy samples submitted to the International Veterinary Renal Pathology Service. Methods Retrospective review of medical records of dogs biopsied for evaluation of proteinuria between January 2015 and May 2017. Results The incidence of FSGS among all dogs biopsied for proteinuria was 26%. Significantly more females (48; 62.3%) than males (29; 37.7%) were affected (P = .04). At the time of biopsy, median serum creatinine concentration (SCr) was 1.2 mg/dL (range, 0.3‐8.7), median serum albumin concentration (Alb) was 2.8 g/dL (range, 1.1‐4.6), median systolic blood pressure was 153.5 mm Hg (range, 95‐260), and median urine protein : creatinine ratio was 5.9 (range, 1.4‐22). Median survival time after biopsy was 258 days (range, 26‐1003) for dogs that died from all causes (n = 32). Factors that were associated with a shorter survival time included SCr ≥ 2.1 mg/dL (P
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