Validation of the PESI Scale to Predict in-Hospital Mortality in Patients with Pulmonary Thromboembolism Secondary to SARS CoV − 2 Infection

Autor: Oscar M Muñoz MD, PhD, Paula Ruiz-Talero MD, Catalina Hernández-Florez MD, Carlos Ernesto Lombo-Moreno MD, MSc, Martha Alejandra Casallas-Rivera MD, Carol Anne Mayorga-Hernández MD
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022)
Druh dokumentu: article
ISSN: 1938-2723
10760296
DOI: 10.1177/10760296221102940
Popis: Objective To evaluate the discriminative ability and the calibration of the Pulmonary Embolism Severity Index (PESI) to predict in-hospital mortality in patients with Pulmonary Embolism (PE) secondary to COVID 19 in two hospitals in Bogotá. Methods External validation study of a prediction model based on a retrospective cohort of patients with PE secondary to COVID-19 treated at Hospital Universitario San Ignacio and Hospital universitario La Samaritana, between March 2020 and August 2021. Calibration of the scale was evaluated using the Hosmer-Lemeshow test and a calibration belt diagram. Discrimination ability was evaluated using a ROC curve. Results 272 patients were included (median age 61.5 years, male 58.8%). PE was diagnosed in 45.6% of the patients at the time of admission. Of the remaining 54.4%, 95.9% received thromboprophylaxis until the time of diagnosis.17.6% of the patients died. Regarding calibration, the scale systematically underestimates risk in all classes of PESI. For class I, the ratio of observed/expected events was 4.4 vs 0.8%, class II 4.8 vs 1.8%, class III 15.2 vs 4.2%, class IV 14.3 vs 5.9% and class V 46.7 vs 5.8%. The calibration test rejected the adequate calibration hypothesis (p
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