The impact of aging and physical training on angiogenesis in the musculoskeletal system

Autor: Magdalena Zmudzka, Jerzy A. Zoladz, Joanna Majerczak
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PeerJ, Vol 10, p e14228 (2022)
Druh dokumentu: article
ISSN: 2167-8359
DOI: 10.7717/peerj.14228
Popis: Angiogenesis is the physiological process of capillary growth. It is strictly regulated by the balanced activity of agents that promote the formation of capillaries (pro-angiogenic factors) on the one hand and inhibit their growth on the other hand (anti-angiogenic factors). Capillary rarefaction and insufficient angiogenesis are some of the main causes that limit blood flow during aging, whereas physical training is a potent non-pharmacological method to intensify capillary growth in the musculoskeletal system. The main purpose of this study is to present the current state of knowledge concerning the key signalling molecules implicated in the regulation of skeletal muscle and bone angiogenesis during aging and physical training.
Databáze: Directory of Open Access Journals