Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study

Autor:	Jiang He, Michael Shlipak, Amanda Anderson, Jason A. Roy, Harold I. Feldman, Radhakrishna Reddy Kallem, Radhika Kanthety, John W. Kusek, Akinlolu Ojo, Mahboob Rahman, Ana C. Ricardo, Elsayed Z. Soliman, Myles Wolf, Xiaoming Zhang, Dominic Raj, Lee Hamm
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	albuminuria chronic kidney disease glomerular filtration rate heart failure risk factor Diseases of the circulatory (Cardiovascular) system RC666-701
Zdroj:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
Druh dokumentu:	article
ISSN:	2047-9980
DOI:	10.1161/JAHA.116.005336
Popis:	BackgroundHeart failure is common in patients with chronic kidney disease. We studied risk factors for incident heart failure among 3557 participants in the CRIC (Chronic Renal Insufficiency Cohort) Study. Methods and ResultsKidney function was assessed by estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C, or both, and 24‐hour urine albumin excretion. During an average of 6.3 years of follow‐up, 452 participants developed incident heart failure. After adjustment for age, sex, race, and clinical site, hazard ratio (95% CI) for heart failure associated with 1 SD lower creatinine‐based eGFR was 1.67 (1.49, 1.89), 1 SD lower cystatin C‐based‐eGFR was 2.43 (2.10, 2.80), and 1 SD higher log‐albuminuria was 1.65 (1.53, 1.78), all P
Databáze:	Directory of Open Access Journals
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