The white matter is a pro-differentiative niche for glioblastoma
Autor: | Lucy J. Brooks, Melanie P. Clements, Jemima J. Burden, Daniela Kocher, Luca Richards, Sara Castro Devesa, Leila Zakka, Megan Woodberry, Michael Ellis, Zane Jaunmuktane, Sebastian Brandner, Gillian Morrison, Steven M. Pollard, Peter B. Dirks, Samuel Marguerat, Simona Parrinello |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
Druh dokumentu: | article |
ISSN: | 2041-1723 86711245 |
DOI: | 10.1038/s41467-021-22225-w |
Popis: | Glioma stem cells (GSCs) retain the ability to partially differentiate, but it is unclear how the brain microenvironment may influence this response. Here the authors show that glioblastoma cells infiltrating into the white matter acquire pre-oligodendrocyte-like fate in a process that mimics myelin repair and results in tumour suppression |
Databáze: | Directory of Open Access Journals |
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