The dose-response effects of flurbiprofen, indomethacin, ibuprofen, and naproxen on primary skeletal muscle cells
| Autor: | Brandon M. Roberts, Alyssa V. Geddis, Ronald W. Matheny |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of the International Society of Sports Nutrition, Vol 21, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 15502783 1550-2783 |
| DOI: | 10.1080/15502783.2024.2302046 |
| Popis: | ABSTRACTBackground Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, flurbiprofen, naproxen sodium, and indomethacin are commonly employed for their pain-relieving and inflammation-reducing qualities. NSAIDs work by blocking COX-1 and/or COX-2, enzymes which play roles in inflammation, fever, and pain. The main difference among NSAIDs lies in their affinity to these enzymes, which in turn, influences prostaglandin secretion, and skeletal muscle growth and regeneration. The current study investigated the effects of NSAIDs on human skeletal muscle cells, focusing on myoblast proliferation, differentiation, and muscle protein synthesis signaling.Methods Using human primary muscle cells, we examined the dose-response impact of flurbiprofen (25–200 µM), indomethacin (25–200 µM), ibuprofen (25–200 µM), and naproxen sodium (25–200 µM), on myoblast viability, myotube area, fusion, and prostaglandin production.Results We found that supraphysiological concentrations of indomethacin inhibited myoblast proliferation (−74 ± 2% with 200 µM; −53 ± 3% with 100 µM; both p |
| Databáze: | Directory of Open Access Journals |
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