Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae.

Autor:	Christopher A Rice, Beatrice L Colon, Emily Chen, Mitchell V Hull, Dennis E Kyle
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Zdroj:	PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e0008353 (2020)
Druh dokumentu:	article
ISSN:	1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0008353
Popis:	Diseases caused by pathogenic free-living amoebae include primary amoebic meningoencephalitis (Naegleria fowleri), granulomatous amoebic encephalitis (Acanthamoeba spp.), Acanthamoeba keratitis, and Balamuthia amoebic encephalitis (Balamuthia mandrillaris). Each of these are difficult to treat and have high morbidity and mortality rates due to lack of effective therapeutics. Since repurposing drugs is an ideal strategy for orphan diseases, we conducted a high throughput phenotypic screen of 12,000 compounds from the Calibr ReFRAME library. We discovered a total of 58 potent inhibitors (IC50
Databáze:	Directory of Open Access Journals
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