Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex

Autor: M. Provansal, G. Labernède, C. Joffrois, A. Rizkallah, R. Goulet, M. Valet, W. Deschamps, U. Ferrari, A. Chaffiol, D. Dalkara, J. A. Sahel, M. Tanter, S. Picaud, G. Gauvain, F. Arcizet
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-021-91972-z
Popis: Abstract Optogenetics has revolutionized neurosciences by allowing fine control of neuronal activity. An important aspect for this control is assessing the activation and/or adjusting the stimulation, which requires imaging the entire volume of optogenetically-induced neuronal activity. An ideal technique for this aim is fUS imaging, which allows one to generate brain-wide activation maps with submesoscopic spatial resolution. However, optical stimulation of the brain with blue light might lead to non-specific activations at high irradiances. fUS imaging of optogenetic activations can be obtained at these wavelengths using lower light power (
Databáze: Directory of Open Access Journals