New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their 'Click' Chemistry Reactions for the Conjugation with closo-Dodecaborate Anion

Autor:	Julia Laskova, Alexander Serdyukov, Irina Kosenko, Ivan Ananyev, Ekaterina Titova, Anna Druzina, Igor Sivaev, Anastasia A. Antonets, Alexey A. Nazarov, Vladimir I. Bregadze
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	coumarins azido derivatives closo-dodecaborate “click” reaction fluorescent labeling cellular uptake Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 23, p 8575 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27238575
Popis:	Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with closo-dodecaborate derivative bearing terminal alkynyl group. CuI catalyzed Huisgen 1,3-dipolar cycloaddition reaction has led to fluorescent conjugates formation. The absorption–emission spectra of the formed conjugates have been presented. The antiproliferative activity and uptake of compounds against several human cell lines were evaluated.
Databáze:	Directory of Open Access Journals
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