Serum IL 6 and umbilical artery Doppler indices in pre-eclamptic patients

Autor: Medhat Y. Anwer, Tark A. Karkor, Sally S. El-Tawab, Akram A. Deghady, Ihab M. El Tayeb
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Alexandria Journal of Medicine, Vol 53, Iss 1, Pp 35-40 (2017)
Druh dokumentu: article
ISSN: 2090-5068
DOI: 10.1016/j.ajme.2016.02.004
Popis: Objectives: To study the changes in serum IL 6 levels in pre-eclamptic patients and to detect any correlation between these changes and changes in the umbilical artery Doppler velocimetry. Methods: In Shatby Hospital, 100 pregnant women, at or beyond 32 weeks were selected and divided into three groups: group A with severe pre-eclampsia, group B with mild pre-eclampsia, and group C with normal pregnancy as control. Measurement of maternal serum IL 6 using ELISA and umbilical artery Doppler velocimetry was done. Kruskal–Wallis, Mann–Whitney U tests, and Spearman’s rank correlation tests were used. Results: A statistical significant difference (p 0.82 ng/dl can be implicated as an early laboratory diagnosis of mild pre-eclampsia. The significant correlation between maternal serum IL 6 levels and Doppler velocimetry supports both the immunologic and the systemic endothelial dysfunction theories of pre-eclampsia.
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