| Autor: |
Oriol Iborra-Egea, Carolina Gálvez-Montón, Santiago Roura, Isaac Perea-Gil, Cristina Prat-Vidal, Carolina Soler-Botija, Antoni Bayes-Genis |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-9 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2056-7189 |
| DOI: |
10.1038/s41540-017-0013-4 |
| Popis: |
Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated a mathematical model to better understand how Sacubitril/Valsartan modulates pathological heart resize and the combined effect of the drug. Our analysis revealed that Sacubitril/Valsartan mainly acts by blocking both, cell death and the pathological makeover of the outer-membrane of the cardiac cells. These two major processes occur after a heart attack. Most importantly, we discovered a core of 8 proteins that emerge as key players in this process. A better understanding of the mechanism of novel cardiovascular drugs at the most basic level may help decipher future therapies and indications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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