| Autor: |
Jaya Gautam, Suhrid Banskota, Hyunji Lee, Yu-Jeong Lee, Yong Hyun Jeon, Jung-Ae Kim, Byeong-Seon Jeong |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Experimental and Molecular Medicine, Vol 50, Iss 9, Pp 1-14 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2092-6413 |
| DOI: |
10.1038/s12276-018-0135-9 |
| Popis: |
Breast cancer: Trapping tumors in place Drugs that inhibit two protein-digesting enzymes could offer potent protection against tumor growth and metastasis in an aggressive form of breast cancer. “Triple-negative breast cancer” (TNBC), which lacks three common tumor biomarkers, carries a poor prognosis for patients, with few treatment options. Enzymes that degrade the protein matrix that anchors tumor cells play a prominent role in metastasis. Researchers led by Jung Ae Kim and Byeong-Seon Jeong at Yeungnam University, Gyeongsan, South Korea, have demonstrated that these enzymes offer potential therapeutic exploitation. The researchers identified a compound that simultaneously suppresses the activity of two different matrix-digesting enzymes. This parallel inhibition markedly reduced tumor growth and metastatic invasion in mouse models of TNBC, with minimal toxicity to non-cancerous cells. This approach could thus offer new hope for treating a challenging class of tumors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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