| Autor: |
Qiumei Liu, Lidong Qin, Yujian Liang, Min Xu, Junling Zhang, Xiaoting Mo, Xu Tang, Yufu Lu, Xuexiu Wang, Jiejing Cao, Chuwu Huang, Jiahui Rong, Kaisheng Teng, Linhai Zhao, Songju Wu, Lei Luo, Qinyi Guan, TianTian Zhang, Wenjia Jin, Jian Qin, Jiansheng Cai, Zhiyong Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Heliyon, Vol 10, Iss 12, Pp e33044- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2405-8440 |
| DOI: |
10.1016/j.heliyon.2024.e33044 |
| Popis: |
Purpose: To date, the relationship between Growth Differentiation Factor 15 (GDF-15) gene polymorphism and the risk of type 2 diabetes mellitus (T2DM) has not been clarified. Our study aims to explore the association between serum GDF-15 levels and related gene polymorphism with the risk of T2DM in a Chinese rural Yao population. Methods: This was a 1:1 case-control study with 179 T2DM patients and 179 age- and sex-matched control participants. Serum GDF-15 levels were measured by enzyme-linked immunosorbent assay, and polymorphisms (rs1059519, rs1059369, rs1804826 and rs1054564) were genotyped by MassArray mass spectrometry. Results: Serum GDF-15 (sGDF-15) levels were higher in patients with T2DM and glycosylated hemoglobin (HbA1c) ≥ 6.5 % compared to that in controls (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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