Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area.

Autor: Xinping Wang, Heng Guo, Yu Li, Haixia Wang, Jia He, Lati Mu, Yunhua Hu, Jiaolong Ma, Yizhong Yan, Shugang Li, Yusong Ding, Mei Zhang, Qiang Niu, Jiaming Liu, Jingyu Zhang, Rulin Ma, Shuxia Guo
Jazyk: angličtina
Rok vydání: 2018
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Zdroj: PLoS ONE, Vol 13, Iss 5, p e0196042 (2018)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0196042
Popis: Gene-gene and gene-environment interactions may be partially responsible for dyslipidemia, but studies investigating interactions in the reverse cholesterol transport system (RCT) are limited. We explored these interactions in a Xinjiang rural population by genotyping five SNPs using SNPShot technique in APOA1, ABCA1, and LCAT, which are involved in the RCT (690 patients, 743 controls). We conducted unconditional logistical regression analysis to evaluate associations and generalized multifactor dimensionality reduction to evaluate interactions. Results revealed significant differences in rs670 and rs2292318 allele frequencies between cases and controls (P
Databáze: Directory of Open Access Journals
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