The assessment of acute toxicity of 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide
| Autor: | O.G. Sechko, V.M. Tsarenkov |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Вестник Витебского государственного медицинского университета, Vol 21, Iss 4, Pp 89-99 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2312-4156 1607-9906 |
| DOI: | 10.22263/2312-4156.2022.4.89 |
| Popis: | Objectives. To evaluate the acute toxicity of a benzamide derivative – 3-[4-(2-fluorobenzoyl)piperazine-1-carbonyl]-N-[3-(trifluoromethyl)-phenyl]benzamide after a single intragastric administration to laboratory mice and rats. Material and methods. Acute toxicity was assessed in experiments on 48 clinically healthy CBA mice of both sexes and 48 clinically healthy Wistar rats of both sexes. The compound under study was administered intragastrically as an aqueous suspension at doses 100 mg/kg, 500 mg/kg and 2000 mg/kg of body weight. The observation duration of intoxication pattern after administration made up 14 days. Changes in body weight of the rodents were determined, autopsy was performed, macroscopic analysis was made, and the weight of the heart, liver, lungs, spleen, and kidneys was determined. The toxicity class of the compound under study was determined by the value of half-lethal dose (LD50). Results. During the experiment, the death of animals was not observed. The general condition of all animals was satisfactory. In each of the experimental groups of mice and rats on days 2, 7 and 14 of the experiment, a statistically insignificant increase in body weight was observed compared to the control group (p>0.05), except for male rats of group №2 (dose 500 mg/kg) – this group had a statistically significant increase in body weight (p |
| Databáze: | Directory of Open Access Journals |
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