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Background The total gestational weight gain is closely related to the gestational week at delivery. Choosing the gestational weight gain rate (GWGR) as a indicator can reduce the interference of gestational week on the results. Currently, available recommendations regarding GWGR are controversial. Few studies have explored the correlation between GWGR in second and third trimesters and delivery outcomes in women with gestational diabetes mellitus (GDM) . Objective To investigate the association of GWGR in second and third trimesters with pregnancy complications and delivery outcomes in women with GDM. Methods A total of 370 women with GDM were selected, who had an experience of undergoing delivery in Hangzhou Women's Hospital from March to December 2018, and were included in the Hangzhou Maternal and Offspring Health Cohort Study (clinical trial registration number: ChiCTR1900026149) . According to GWGR in second and third trimesters recommended by the Weight Monitoring and Evaluation during Pregnancy Period of Chinese Women published by the Chinese Nutrition Society in 2021, the subjects were divided into insufficient GWGR group (n=115) , normal GWGR group (n=152) and excessive GWGR group (n=103) . We analyzed the incidence of pregnancy complications and delivery outcomes of the three groups. Results Logistic regression analysis demonstrated that excessive GWGR in second and third trimesters was associated with an increased risk of hypertensive disorders of pregnancy〔OR=2.661, 95%CI (1.291, 9.460) 〕, gestational hypothyroidism〔OR=2.288, 95%CI (1.090, 4.805) 〕, gestational hyperlipidemia〔OR=2.085, 95%CI (1.656, 6.630) 〕 and macrosomia〔OR=4.591, 95%CI (1.238, 17.031) 〕 (P |
