Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies

Autor:	Yan Dong, Zhuo Wan, Xiaotong Gao, Guodong Yang, Li Liu
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	cancer immune therapy cell engineering targets strategies immune cells Immunologic diseases. Allergy RC581-607
Zdroj:	Frontiers in Immunology, Vol 12 (2021)
Druh dokumentu:	article
ISSN:	1664-3224 88203204
DOI:	10.3389/fimmu.2021.609762
Popis:	Cancer is one of the leading causes of death and a major public health problem all over the world. Immunotherapy is becoming a revolutionary clinical management for various cancer types. Restoration of aberrant immune surveillance on cancers has achieved markable progress in the past years by either in vivo or ex vivo engineering of the immune cells. Here, we summarized the central roles of immune cells in tumor progression and regression, and the existing and emerging strategies for different immune cell-based immunotherapies. In addition, the current challenges and the potential solutions in translating the immunotherapies into the clinic are also discussed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1d88203204a5473fa76c648e8bfb0e71 Zobrazit plný text záznamu View record in DOAJ