| Autor: |
Ashkan Zandi, Fatemeh Shojaeian, Fereshteh Abbasvandi, Mohammad Faranoush, Robab Anbiaee, Parisa Hoseinpour, Ali Gilani, Mohammad Saghafi, Afsoon Zandi, Meisam Hoseinyazdi, Zahra Davari, Seyyed Hossein Miraghaie, Mahtab Tayebi, Morteza Sanei Taheri, S. Mehdi Samimi Ardestani, Zahra Sheikhi Mobarakeh, Mohammad Reza Nikshoar, Mohammad Hossein Enjavi, Yasin Kordehlachin, S. M. Sadegh Mousavi-kiasary, Amir Mamdouh, Mohammad Esmaeil Akbari, Masud Yunesian, Mohammad Abdolahad |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2023.1195026 |
| Popis: |
BackgroundCorrelative interactions between electrical charges and cancer cells involve important unknown factors in cancer diagnosis and treatment. We previously reported the intrinsic suppressive effects of pure positive electrostatic charges (PEC) on the proliferation and metabolism of invasive cancer cells without any effect on normal cells in cell lines and animal models. The proposed mechanism was the suppression of pro-caspases 3 and 9 with an increase in Bax/Bcl2 ratio in exposed malignant cells and perturbation induced in the KRAS pathway of malignant cells by electrostatic charges due to the phosphate molecule electrostatic charge as the trigger of the pathway. This study aimed to examine PECs as a complementary treatment for patients with different types of solid metastatic tumors, who showed resistance to chemotherapy and radiotherapy.MethodsIn this study, solid metastatic tumors of the end-stage patients (n = 41) with various types of cancers were locally exposed to PEC for at least one course of 12 days. The patient’s signs and symptoms, the changes in their tumor size, and serum markers were followed up from 30 days before positive electrostatic charge treating (PECT) until 6 months after the study.ResultsEntirely, 36 patients completed the related follow-ups. Significant reduction in tumor sizes and cancer-associated enzymes as well as improvement in cancer-related signs and symptoms and patients’ lifestyles, without any side effects on other tissues or metabolisms of the body, were observed in more than 80% of the candidates.ConclusionPECT induced significant cancer remission in combination with other therapies. Therefore, this non-ionizing radiation would be a beneficial complementary therapy, with no observable side effects of ionizing radiotherapy, such as post-radiation inflammation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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