Comparison of characteristics and outcomes of young‐onset versus average onset pancreatico‐biliary adenocarcinoma

Autor:	Thejus Jayakrishnan, Kanika G. Nair, Suneel D. Kamath, Wei Wei, Bassam N. Estfan, Smitha S. Krishnamurthi, Alok A. Khorana
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	biliary cancers cholangiocarcinoma disparity epidemiology pancreatic adenocarcinoma young‐onset cancers Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 12, Iss 6, Pp 7327-7338 (2023)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.5418
Popis:	Abstract Background Young‐onset gastrointestinal malignancies appear to be increasing in incidence. There are limited data on young‐onset pancreaticobiliary adenocarcinoma (YO‐PBA). Methods The study comprised patients with PBA (pancreatic adenocarcinoma, intra‐, and extra‐hepatic cholangiocarcinoma) and included in the National Cancer Database (NCDB) between 2004 and 2017. YO‐PBA was defined as a diagnosis at age less than 50 years. Logistic regression to assess factors associated with YO‐PBA status, and cox proportional hazards modeling to associate relevant factors with overall survival was performed. Results The study cohort comprised 360,764 patients, with 20,822 (5.8%) YO‐PBA. YO‐PBA was associated with (p‐values
Databáze:	Directory of Open Access Journals
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