| Autor: |
Yumiko Tsuchiya, Hirohito Kobayashi, Hitoshi Kanno, Toshiyuki Yamamoto |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Tokyo Women's Medical University Journal, Vol 6, Iss 0, Pp 101-107 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2432-6186 |
| DOI: |
10.24488/twmuj.2022012 |
| Popis: |
Objective: γδ T cells can recognize and attack cancer cells even in the absence of information from dendritic cells. γδ T cells have been used in immune cell therapy because of their strong ability to kill cancer cells. However, the number of γδ T cells in peripheral blood is small; therefore, it is important to increase the number of γδ T cells via effective ex vivo culturing. Methods: In this study, we analyzed the effects of beta-tricalcium phosphate (β-TCP) on γδ T cells derived from peripheral blood. Results: We confirmed that the number of γδ T cells increased via β-TCP addition to the culture medium in 83.3% of the experiments (5/6 times). Conclusion: As β-TCP has been widely used in medical therapy, it may be used as a possible adjuvant in γδ T-cell-based immune therapy for human disorders. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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