The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS

Autor:	Jasmine Harley, Benjamin E. Clarke, Rickie Patani
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	RNA binding protein oxidative stress mitochondrial dysfunction ALS Therapeutics. Pharmacology RM1-950
Zdroj:	Antioxidants, Vol 10, Iss 4, p 552 (2021)
Druh dokumentu:	article
ISSN:	10040552 2076-3921
DOI:	10.3390/antiox10040552
Popis:	RNA binding proteins fulfil a wide number of roles in gene expression. Multiple mechanisms of RNA binding protein dysregulation have been implicated in the pathomechanisms of several neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Oxidative stress and mitochondrial dysfunction also play important roles in these diseases. In this review, we highlight the mechanistic interplay between RNA binding protein dysregulation, oxidative stress and mitochondrial dysfunction in ALS. We also discuss different potential therapeutic strategies targeting these pathways.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1d5d0483941e4315919ef288bdf80123 Zobrazit plný text záznamu View record in DOAJ