Asymmetric carbohydroxylation of alkenes via sequential photocatalytic oxo-alkylation and enzymatic reduction

Autor:	Yiyin Liu, Kun Zhu, Xuemei Li, Xiaoyun Wu, Jinhui Feng, Atefeh Roosta, Qiaqing Wu, Dunming Zhu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Alkene difunctionlization Carbohydroxylation Photoredox catalysis Biocatalysis Chiral alcohols Organic chemistry QD241-441
Zdroj:	Tetrahedron Chem, Vol 11, Iss , Pp 100083- (2024)
Druh dokumentu:	article
ISSN:	2666-951X 75002477
DOI:	10.1016/j.tchem.2024.100083
Popis:	Asymmetric carbohydroxylation of alkenes offers an efficient approach to access chiral alcohols, a class of versatile building blocks in pharmaceutical and agrochemical industries, from abundant simple alkenes. Herein we reported a sequential photo-biocatalysis protocol for the asymmetric carbohydroxylation of alkenes, involving a stepwise photocatalytic decarboxylative radical addition/Kornblum oxidation and enzymatic reduction. A series of chiral alcohols with bulky structures were synthesized in up to 75 % isolated yields and 99 % ee from N-hydroxyphthalimide esters and aryl alkenes.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1d54d1d75002477182a12bef64f5b9ce Zobrazit plný text záznamu View record in DOAJ